creos xenoprotect – experience the difference

The resorbable collagen membrane with outstanding handling properties and an extended barrier function

Collagen membrane

Overhead view showing a dense meshwork, primarily composed of highly interwoven collagen fibers. The enlarged circular detail reveals collagen fibrils in their typical cross-striated appearance. Magnification 10'000x.

creos xenoprotect is a resorbable, non-chemically cross-linked membrane for guided bone regeneration (GBR) and guided tissue regeneration (GTR) procedures. It's composed of a network of interwoven, highly purified porcine collagen and elastin fibers, providing the membrane with very high mechanical strength. The dense mesh holds the bone graft material securely in place, preventing the migration of undesired cells for undisturbed healing.

Why creos xenoprotect?

Reliable and long-lasting barrier function

Due to the unique manufacturing process of creos xenoprotect, the membrane is highly resistant to degradation, leading to stable and prolonged protection of the graft material.1 This is achieved without any chemical cross-linking, ensuring optimal conditions for tissue integration.

Outstanding handling – saves you valuable time

A noticeable difference when applying the creos xenoprotect membrane is the ease of repositioning and unfolding as it doesn't become sticky when hydrated. It's rehydrated within seconds and adheres well to the defect shape. What's more, the membrane can be cut and pre-shaped according to the specific defect without having to consider any major size increase when moistened.2

Easy to stretch and suture

creos xenoprotect is highly tear resistant due to its high mechanical strength, and its elastin fibers make the membrane stretchable.1 This makes it easy to stretch over the defect area and suture without fear of rupturing the membrane.

Fast and predictable tissue healing

Thanks to the unique manufacturing process, the tissue integration and vascularization properties of the membrane are not compromised.1 Histologies clearly show the rapid formation of new blood vessels, which lead to fast and more predictable tissue healing.

Three sizes - limited waste

Whether larger bone augmentations or smaller periodontal defects, the optimal fit can be found without extensive trimming. This limits waste and minimizes costs for you and your patients. creos xenoprotect is available in three different sizes: 15x20 mm, 25x30 mm and 30x40 mm.


Dr. Giorgio Tabanella, Italy – GBR and simultaneous implant placement

Situation: Missing mandibular first molar, crestal bone resorption.

Solution: GBR procedure using creos xenoprotect collagen membrane for augmentation of implant dehiscence after placement of a NobelReplace Conical Connection implant.

Dr. Fabrice Clipet, France – Augmentation after immediate implant placement

Situation: 7 mm buccal probing and mild root resorption at upper central incisor (tooth #21).  

Solution: Removal of hopeless tooth with immediate placement of NobelActive implant, bone grafting with a mix of autogenous bone and deproteinized bovine bone matrix (DBBM), covered by a creos xenoprotect collagen membrane.

View case (PDF, 179 kB)

Prof. Dr. Mariano Sanz, Spain – Extraction socket preservation

Situation: Periapical infection and an open fistulous track toward the root of upper central incisor (tooth #21). Presence of a perio-endo lesion and tooth is extracted. Loss of the buccal bone plate so a lateral bone augmentation procedure is indicated.

Solution: Deproteinized bovine bone mineral (DBBM) is used as scaffold and creos xenoprotect as a protective barrier. An implant is placed after six months of uneventful healing.

View case (PDF, 230 kB)

Dr. Philippe Russe, France – Horizontal ridge augmentation

Situation: Trauma on both upper central incisors in 1994. Teeth were re-implanted and extraction done in November 2012.

Solution: Horizontal ridge augmentation using processed allogenic bone graft and a creos xenoprotect collagen membrane. Placement of two NobelActive implants after six months of healing.

View case (PDF, 725 kB)

Dr. Oscar Gonzalez-Martin, Spain – Extraction socket preservation

Situation: Fractured first maxillary left premolar, tooth extraction indicated.  

Solution: GBR procedure and delayed implant placement.

View case (PDF, 442 kB)

Dr. Javier Alandez, Spain – Extraction socket preservation

Situation: Fractured first maxillary left premolar, tooth extraction indicated. 

Solution: The defect is filled by using bovine hydroxyapatite. A creos xenoprotect collagen membrane is applied to cover the defect. After three months, reopening of the treated area shows complete regeneration of the initial defect.

View case (PDF, 367 kB)

Dr. Giorgio Tabanella, Italy – Maxillary sinus elevation

Situation: Extraction of hopeless upper first molar, pneumatized maxillary sinus with insufficient bone volume for implant placement.

Solution: Maxillary sinus elevation using creos xenoprotect to cover lateral window.

Dr. Giorgio Tabanella, Italy – Horizontal augmentation

Situation: Both upper lateral incisors missing, narrow ridge and insufficient bone volume for implant placement. 

Solution: GBR procedure using creos xenoprotect collagen membrane for horizontal ridge augmentation.


Bozkurt A et al.

Bozkurt A, Apel C, Sellhaus B, van Neerven S, Wessing B, Hilgers R-D, Pallua N. Differences in degradation behavior of two non-cross-linked collagen barrier membranes: an in vitro and in vivo study. Clin. Oral Impl. Res. 00, 2013, 1–9 doi: 10.1111/clr.12284 [Epub ahead of print]

To read summary of results, download the Science First leaflet in the literature tab.

Read full study

Wessing et al. Clin Oral Impl Res. 2013 (Supplement s9)

Wessing B, Bozkurt A, Sellhaus B, Emmerich M. GBR with a mechanically stable resorbable membrane as a potential alternative to autogenous bone block grafts. Clin Oral Impl Res. October 2013:24(Supplement s9);153-154. DOI:10.1111/clr.12249.

Read poster abstract

Implantologie Journal 2011/12 Special Print

Implantologie Journal Special Print (SPECIAL PRINT Edition 5/11 and 5/12 • Volume 16) - Dr med. dent. Bastian Wessing, Dr. med. dent. Martin Emmerich, MSc 

“New Materials in GBR” and “Safe Bone Regeneration Through a New Collagen Membrane”

Read publication

Jahrbuch Implantologie 2014 Special Print

Jahrbuch Implantologie (SPECIAL PRINT Edition 2014 • Volume 20) - Dr med. dent Bastian Wessing, Dr med. dent. Martin Emmerich, MSc 

“What is Guided Bone Regeneration (GBR) Capable of Today?”

Read publication

Arrighi I et al.

Arrighi I, Wessing B, Rieben A, De Haller E.
Resorbable Collagen Membranes Expansion
In Vitro. J. Dent. Res 93 (Special Issue B):#631, 2014 (

Read poster


Prof. Christer Dahlin, Sweden

Prof. Christer Dahlin, Sweden

“I really like the handling of the material. The fact that it doesn’t lose its shape when you place it, is a great benefit. It gives you the possibility to take out the membrane and trim it. After a minute or so, when it is soaked, it attaches very nicely to the bone surface and no fixation seems to be necessary.”

Dr. Ramón Buenechea, Spain

Dr. Ramón Buenechea, Spain

“It is a thin, easy to handle and quickly moistened membrane that maintains its properties as a barrier. It allows suturing and/or tag fixation and is easily adapted to the bone defect.”

Dr. Angel Fernandez Bustillo, Spain

Dr. Angel Fernandez Bustillo, Spain

“For over a decade I have used collagen membranes to achieve excellent results.  Each type of membrane offered varying benefits. Nobel Biocare has managed to integrate most of them. I was surprised by its rapid and uniform hydration. It is easy to cut and it does not fold itself together. It is ideal for maxillary sinus lift and bone regeneration.”

Dr. Ali Tahmaseb, Netherlands

Dr. Ali Tahmaseb, Netherlands (private practice, Antwerp, Belgium)

“I like the membrane because it's very easy to handle compared to other membranes I’ve used. The most important thing for me is the extended resorption time – the membrane stays in place longer.”

Dr. Bastian Wessing, Germany

Dr. Bastian Wessing, Germany

“We are very excited about this new membrane. We have better results with creos xenoprotect than with the membranes we have used before. What I like is that the handling is very easy. The mechanical stability is very high and when it is rehydrated it adapts very well to the underlying bone.”



Already a Nobel Biocare customer?
Log in to your personal MyNobel portal to access additional literature, handling instructions and guidelines in My Library.


Bozkurt A, Apel C, Sellhaus B, van Neerven S, Wessing B, Hilgers R-D, Pallua N. Differences in degradation behavior of two non-cross-linked collagen barrier membranes: an in vitro and in vivo study. Clin. Oral Impl. Res. 00, 2013, 1-9 doi: 10.1111/clr.12284 [Epub ahead of print]*

* Since 2013 the Remaix™ membrane (Matricel GmbH, Germany) has been marketed as creos xenoprotect by Nobel Biocare.

Read on Wiley Online

Arrighi I, Wessing B, Rieben A, De Haller E. Resorbable Collagen Membranes Expansion In Vitro. J. Dent. Res 93 (Spec Iss B):#631, 2014

Read the poster